The Importance of Methylation Genetic Testing (DNA)

Unveiling Your Health Blueprint

Almost every metabolic process in the body involves methylation, which technically entails adding methyl groups to other molecules. It occurs billions of times every second in our cells and contributes to numerous crucial functions.

Imbalances in this process can increase susceptibility to chronic health conditions such as heart disease, circulatory problems, chronic fatigue, infertility, immune and autoimmune conditions, food and chemical sensitivities, and mood and psychiatric disorders, as well as cancer and premature ageing.

Fortunately, advances in technology have made it easier to explore our genetic makeup. Home DNA tests can reveal our methylation profile, giving us insights into our genetic strengths and weaknesses.

So, why does it matter?

You inherit your methylation genes – one from each parent. Sometimes, variations on these genes, also known as a polymorphism or SNP (pronounced “snip”), can disrupt this delicate balance, potentially impacting your health. Both pairs of genes may be functioning optimally, or maybe one or both are not – making the cycle work too fast, too slow, or inefficiently. Knowing this information can help you tailor your approach to health. By understanding your genetics, you can personalize your diet, lifestyle, and supplements to support better methylation and reduce health risks.

Armed with genetic info, you can adjust your habits to better suit your unique genetic makeup.

It’s not just about fixing problems; it’s about preventing them too. By identifying genetic vulnerabilities early, you can take proactive steps to avoid potential health issues and lead a longer, healthier life.

Your methylation genetics hold valuable clues to your health journey. By unlocking this genetic puzzle, you can navigate towards better health outcomes. You can’t change the genes you’ve inherited, but you can leverage them to shape your health story.

Want to know more?

What genes do I look at specifically?

I look at the entire methylation cycle, including some key genes:

1. The enzyme Methylenetetrahydrofolate Reductase (MTHFR) plays a role in converting the amino acid homocysteine to methionine, which is crucial for various bodily functions. Variations in the MTHFR gene can impact this process and have links to conditions such as heart disease, neural tube defects, and mood disorders.
2. MTR (Methionine Synthase) is an enzyme that helps convert homocysteine into methionine, an essential building block for the body. Changes in the MTR gene can affect this conversion, leading to high homocysteine levels. This can contribute to conditions like heart disease and problems with the gut, such as inflammatory bowel disease. Genetic variations in MTR and MTRR have also linked deficiencies to neurological disorders, including cognitive impairment, peripheral neuropathy, and psychiatric symptoms.
3. MTRR (Methionine Synthase Reductase) is an enzyme that helps maintain the activity of methionine synthase (MTR) by regenerating the active form of vitamin B12 (methylcobalamin). This process is essential for efficient remethylation and proper functioning of the methylation cycle.
4. The enzyme Catechol-O-Methyltransferase (COMT) plays a role in methylating catecholamines, such as dopamine, epinephrine, and norepinephrine. It plays a crucial role in the breakdown of neurotransmitters in the brain and peripheral tissues. Variations in the COMT gene can affect enzyme activity, potentially influencing neurotransmitter levels and contributing to individual differences in behaviour, cognition, and emotional responses. Researchers have associated variations with an increased susceptibility to psychiatric disorders, such as schizophrenia, bipolar disorder, anxiety disorders, and attention deficit hyperactivity disorder (ADHD). The COMT enzyme plays a role in the metabolism of dopamine, a neurotransmitter implicated in the pathophysiology of these disorders.
5. The enzyme S-Adenosylhomocysteine Hydrolase (AHCY) plays a role in breaking down S-adenosylhomocysteine (SAH), a byproduct of methylation reactions. AHCY catalyzes the conversion of SAH to adenosine and homocysteine, completing the methylation cycle. Dysregulation of AHCY activity can disrupt the balance of methylation and impact cellular function. Researchers have implicated variations in the AHCY gene in the pathogenesis of liver diseases, including liver fibrosis, cirrhosis, and hepatocellular carcinoma. Researchers have associated altered SAH metabolism with neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, although further research is needed to elucidate the underlying mechanisms.

Overall, these genes play critical roles in the methylation pathway, influencing various aspects of health and well-being. Variations in these genes can affect methylation efficiency and contribute to the development of certain health conditions, highlighting the importance of understanding individual genetic predispositions for personalized health management strategies.

DNA Methylation Testing starts at £400. Contact me for more information.